TY - CHAP M1 - Book, Section TI - Chapter 137. Principles of Epidemiology and Research Design A1 - Osterhoudt, Kevin C. A2 - Nelson, Lewis S. A2 - Lewin, Neal A. A2 - Howland, Mary Ann A2 - Hoffman, Robert S. A2 - Goldfrank, Lewis R. A2 - Flomenbaum, Neal E. PY - 2011 T2 - Goldfrank's Toxicologic Emergencies, 9e AB - Advances in medical toxicology are achieved through the scientific method using observations, derived from cases of poisoning and nonpoisoning due to xenobiotic exposures, to generate hypotheses. Subsequent research questions are analyzed with epidemiological investigation, and preliminary studies are examined with methodological scrutiny. Initial analytical techniques are improved, and confirmatory studies are performed. Ultimately, models relating cause to effect are formulated. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2021/01/18 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=6534443 ER -