TY - CHAP M1 - Book, Section TI - Nonsteroidal Antiinflammatory Drugs A1 - Holubek, William J. A2 - Hoffman, Robert S. A2 - Howland, Mary Ann A2 - Lewin, Neal A. A2 - Nelson, Lewis S. A2 - Goldfrank, Lewis R. PY - 2015 T2 - Goldfrank's Toxicologic Emergencies, 10e AB - In the late 1800s, acetylsalicylic acid, aspirin, was shown to have antiinflammatory properties similar to those of corticosteroids when used in high doses in patients with rheumatoid arthritis. In a quest to develop a compound with antiinflammatory properties equivalent to corticosteroids but chemically nonsteroidal, Dr. Stewart Adams discovered and developed 2-(4-isobutylphenyl) propionic acid, now known as ibuprofen, and in the process created a new class of drugs designated as nonsteroidal antiinflammatory drugs (NSAIDs).35 Ibuprofen was initially marketed in the United Kingdom in 1969 and was introduced to the US market in 1974. Ibuprofen became available without a prescription in the United States in 1984. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1108427970 ER -