TY - CHAP M1 - Book, Section TI - Shock A1 - Bandyopadhyay, Subhankar A1 - Ugalde, Irma A2 - Stone, C. Keith A2 - Humphries, Roger L. A2 - Drigalla, Dorian A2 - Stephan, Maria PY - 2014 T2 - CURRENT Diagnosis & Treatment: Pediatric Emergency Medicine AB - Any condition that results in inadequate tissue oxygen delivery triggers an autonomic response in human body to maintain homeostasis. A cellular response to decreased oxygen delivery activates cascades of physiologic compensatory mechanisms to maintain normal functions. Therefore, in a state of shock, inadequate oxygen delivery fails to meet cellular metabolic demands and results in global tissue hypoperfusion and metabolic acidosis. Cellular response to decreased oxygen delivery causes adenosine triphosophate (ATP) depletion, energy-dependent ion pump dysfunction, and loss of cell membrane integrity. These events lead to systemic lactic acidosis with overpowering of various compensatory mechanisms that progress to multiple organ failure and ultimately death. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1106019661 ER -