TY - CHAP M1 - Book, Section TI - Skin Signs of Systemic Disease A1 - Festekjian, Ara A1 - Wang, Vincent J A2 - Schafermeyer, Robert A2 - Tenenbein, Milton A2 - Macias, Charles G. A2 - Sharieff, Ghazala Q. A2 - Yamamoto, Loren G. PY - 2014 T2 - Strange and Schafermeyer's Pediatric Emergency Medicine, 4e AB - Erythema nodosum (EN) is an acute panniculitis consisting of deep, painful, bilateral, erythematous nodules, usually on the lower extremities, resulting from an underlying systemic illnessErythema multiforme (EM) is an acute, immune-mediated mucocutaneous condition characterized by target lesions with concentric zones of color change, most commonly associated with herpes simplex virus (HSV) infectionStevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe immune-mediated hypersensitivity reactions characterized by diffuse bullous lesions and mucocutaneous involvement most commonly precipitated by medications such as anticonvulsantsStaphylococcal scalded skin syndrome (SSSS) is characterized by an erythematous rash followed by diffuse epidermal exfoliationPurpura fulminans is a severe form of rapidly progressive purpura with multiorgan failure, usually associated with meningococcemiaNonaccidental trauma should be suspected if bruising occurs on nonbony prominences or in areas not normally subjected to trauma during routine child playToxic shock syndrome (TSS) is an acute, toxin-mediated illness characterized by fever, erythroderma, hypotension, multiorgan involvement, and desquamation. Streptococcal TSS (STSS) is a similar disease caused by invasive group A Streptococcus (GAS). Each of these is a shock state.Necrotizing fasciitis (NF) is a rapidly progressive, life and limb threatening infection by virulent bacteria with severe inflammation of the fascia and surrounding subcutaneous tissuesKawasaki disease (KD) is an acute, self-limited, vasculitic syndrome in children. The diagnosis is established clinically by the presence of prolonged fever and four of the following five clinical features: conjunctival injection, oropharynx erythema, cervical lymphadenopathy, hand and foot erythema/swelling, and rash.Urticaria, often referred to as hives, appears as blanchable, pruritic, raised, well-circumscribed areas of edema and erythema involving the epidermis and dermisAngioneurotic edema (AE) is a self-limited localized swelling due to extravasation of fluid into interstitial tissues, most commonly involving the head, neck, hand, and gastrointestinal tract. Laryngeal involvement is life-threatening. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/01 UR - accessemergencymedicine.mhmedical.com/content.aspx?aid=1105685327 ER -