RT Book, Section
A1 Levine, Michael
A1 Skolnik, Aaron B.
A2 Tintinalli, Judith E.
A2 Stapczynski, J. Stephan
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Cline, David M.
SR Print(0)
ID 1132928898
T1 Digitalis Glycosides
T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071794763
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1132928898
RD 2024/04/19
AB The  medicinal  benefits  of  cardiac  glycosides  have  been  recognized  for  centuries,  and  even  with  other  alternative  medications,  digitalis  preparations,  such  as  digoxin,  are  still  used  for  the  treatment  of  atrial  fibrillation  and  symptomatic  congestive  heart  failure.1  In  addition  to  availability  as  pharmaceuticals,  cardiac  glycosides  are  also  found  in  plants  such  as  foxglove,  oleander,  red  squill,  and  lily  of  the  valley.  Similar  cardioactive  steroids  are  also  found  in  the  skin  of  toads  in  the  Bufonidae  family  and  in  some  herbal  medications.  Despite  declining  use  of  digoxin,  the  prevalence  of  patients  diagnosed  with  digoxin  toxicity  has  remained  constant,  and  the  use  of  digoxin-specific  antibody  fragments  has  increased.2  Digitoxin,  a  cardiac  glycoside  similar  in  structure  to  digoxin  but  with  a  longer  half-life,  is  no  longer  commercially  available  in  the  United  States,  but  is  available  in  Canada  and  elsewhere  in  the  world.