RT Book, Section A1 Liang, Stephen Y. A2 Tintinalli, Judith E. A2 Stapczynski, J. Stephan A2 Ma, O. John A2 Yealy, Donald M. A2 Meckler, Garth D. A2 Cline, David M. SR Print(0) ID 1132927698 T1 Toxic Shock Syndromes T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071794763 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1132927698 RD 2024/03/29 AB The two classic toxic shock syndromes are attributed to Staphylococcus aureus or to group A Streptococcus (Streptococcus pyogenes). Each is a life-threatening illness stemming from toxin production by gram–positive organisms, creating hemodynamic compromise and fulminant multiorgan dysfunction. This cascade makes diagnosis a challenge, with the features looking like the more common entities of sepsis and septic shock. Characteristic epidemiology, pathophysiology, clinical presentations, and management strategies set these syndromes apart (Table 150–1). Early recognition and definitive treatment are the keys to improving patient outcomes.