RT Book, Section A1 Schneider, Sandra M. A1 Cobaugh, Daniel J. A1 Kessler, Benjamin D. A2 Tintinalli, Judith E. A2 Stapczynski, J. Stephan A2 Ma, O. John A2 Yealy, Donald M. A2 Meckler, Garth D. A2 Cline, David M. SR Print(0) ID 1132928568 T1 Lithium T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071794763 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1132928568 RD 2024/04/24 AB Lithium is one of the most effective medications for the continuous treatment of bipolar disorder. It is particularly useful for the treatment of acute manic episodes and reduces rates of suicide associated with affective disorders.1,2,3 Off-label uses for lithium include augmentation of the action of other antidepressant drugs and treatment of aggression, posttraumatic stress disorder, and pediatric conduct disorders. Lithium for the treatment of Alzheimer's disease is under investigation.4 Lithium toxicity most often results from accidental or intentional overdose, increased dose, or reduction in renal clearance of lithium.