RT Book, Section A1 Rella, Joseph G. A1 Carter, Wallace A. A2 Tintinalli, Judith E. A2 Stapczynski, J. Stephan A2 Ma, O. John A2 Yealy, Donald M. A2 Meckler, Garth D. A2 Cline, David M. SR Print(0) ID 1121513447 T1 Antimicrobials T2 Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071794763 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1121513447 RD 2024/10/11 AB Adverse effects associated with antimicrobials occur primarily in three circumstances: side effects with therapeutic dosing, acute toxicity resulting from excessive dosing, and subacute to chronic effects from sustained therapeutic use. Side effects can be immunologic (allergic) or nonimmunologic (pharmacologic or idiosyncratic) in nature. Antibiotics cause more reported allergic reactions than other drugs, possibly due to their high frequency of use that is often in a repeated and interrupted fashion. Sometimes a diluent or other chemical constituent in the formulation of a drug causes the adverse effect.