RT Book, Section A1 Marcolini, Evie G. A1 Chiu, William C. A2 Farcy, David A. A2 Chiu, William C. A2 Marshall, John P. A2 Osborn, Tiffany M. SR Print(0) ID 1135702711 T1 Adrenal Insufficiency T2 Critical Care Emergency Medicine, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071838764 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1135702711 RD 2024/03/28 AB Adrenal gland function has provided great academic material for investigation and controversy. It was not until 1937 that 17-hydroxy-11-dehydrocorticosterone, or cortisone, was isolated by Reichstein from the adrenal cortex. By 1947, synthetic cortisone was developed. At the same time, in addition to the use of cortisone for Addison disease, this compound was found to have a therapeutic effect in patients with rheumatoid pain through its ability to inhibit stress and inflammation.