RT Book, Section A1 Podolsky, Seth R. A1 Campbell, Matthew J. A2 Farcy, David A. A2 Chiu, William C. A2 Marshall, John P. A2 Osborn, Tiffany M. SR Print(0) ID 1135703445 T1 Acetaminophen Overdose T2 Critical Care Emergency Medicine, 2e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9780071838764 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1135703445 RD 2024/04/18 AB Acetaminophen is the most widely used analgesic and a commonly used antipyretic. It has been available as an over-the-counter formulation for more than 50 years and is exceptionally safe when used according to manufacturer directions.1 Unfortunately, toxic levels can make it a silent and lethal killer because overdose may initially present with few, if any, symptoms.2–5 If not promptly discovered and treated, acetaminophen toxicity can lead to liver failure and death unless a successful liver transplant is performed.5–11