RT Book, Section A1 Synovitz, Carolyn K. A2 Cydulka, Rita K. A2 Fitch, Michael T. A2 Joing, Scott A. A2 Wang, Vincent J. A2 Cline, David M. A2 Ma, O. John SR Print(0) ID 1143140224 T1 Arterial Occlusion T2 Tintinalli's Emergency Medicine Manual, 8e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071837026 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1143140224 RD 2024/04/23 AB Peripheral arterial disease is defined as an ankle-brachial index (ABI) of <0.9 (see ABI definition below). The disease prevalence is 4.3% in Americans under age 40 years, and prevalence climbs to 15.5% in those over 70 years of age. High-risk individuals (such as those over 70 years, or those over 50 years with risk factors such as diabetes) should be evaluated carefully when complaints are indicative of possible occlusive arterial disease. Tobacco use significantly increases the risks that an individual will develop peripheral arterial disease. Limb ischemia from an acute arterial occlusion can lead to irreversible changes in peripheral nerves and skeletal muscle tissue in 4 to 6 hours. The most frequently diseased arteries leading to limb ischemia are the femoropopliteal, tibial, aortoiliac, and brachiocephalic. The common femoral and popliteal arteries are the most common sites of arterial embolism.