RT Book, Section A1 Chang, Todd P. A2 Cydulka, Rita K. A2 Fitch, Michael T. A2 Joing, Scott A. A2 Wang, Vincent J. A2 Cline, David M. A2 Ma, O. John SR Print(0) ID 1143141377 T1 Fever and Serious Bacterial Illness in Children T2 Tintinalli's Emergency Medicine Manual, 8e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071837026 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1143141377 RD 2024/04/19 AB Fever is the most common pediatric chief complaint presenting to an emergency department (ED) and accounts for 30% of outpatient visits. Infants and children are at relatively high risk for serious bacterial illness (SBI), which includes urinary tract infection (UTI), pneumonia, bacteremia or sepsis, and meningitis—in decreasing prevalence. Neonates are at the highest risk due to their immature immune response, while infants from 1 to 3 months of age gradually transition to the lower risk profile of older infants and children. The incidence of UTI is 5% overall in children 2 months to 2 years, with a prevalence of 3% to 8% in all febrile children visiting an ED. Widespread vaccination has dropped the incidence of occult bacteremia for children 3 to 36 months of age to 0.5% to 0.7%, with further decreases expected with the 13-valent pneumococcal conjugate vaccine. Meningitis risk decreases from about 1% in the first month of life to <0.1% later in infancy and childhood.