RT Book, Section A1 Kefer, Michael P. A2 Cydulka, Rita K. A2 Fitch, Michael T. A2 Joing, Scott A. A2 Wang, Vincent J. A2 Cline, David M. A2 Ma, O. John SR Print(0) ID 1143143509 T1 Adrenal Insufficiency T2 Tintinalli's Emergency Medicine Manual, 8e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071837026 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1143143509 RD 2024/04/19 AB Adrenal insufficiency results when the physiologic demand for glucocorticoids and mineralocorticoids exceeds the supply from the adrenal cortex. The pituitary secretes adrenocorticotropin hormone (ACTH) and associated melanocyte stimulating hormone (MSH). ACTH stimulates the adrenal cortex to secrete cortisol. Cortisol has negative feedback on the pituitary to inhibit secretion of ACTH and MSH.