RT Book, Section A1 Sivilotti, Marco L. A. A2 Tenenbein, Milton A2 Macias, Charles G. A2 Sharieff, Ghazala Q. A2 Yamamoto, Loren G. A2 Schafermeyer, Robert SR Print(0) ID 1155748586 T1 Aspirin T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 5e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259860751 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1155748586 RD 2024/03/28 AB Salicylate poisoning is difficult to treat, and consultation with a medical toxicologist is recommended.Children with aspirin toxicity can rapidly develop metabolic acidosis without an apparent respiratory alkalosis.Initial treatment decisions should be predicated on mental status, tachypnea, symptoms such as hearing distortion and blood gases rather than waiting for a serum salicylate concentration.Treatment of mild-to-moderate aspirin poisoning consists of slowing ongoing absorption, correcting volume and electrolyte deficits, alkalinizing the urine, and frequent clinical and laboratory reassessments.Severe aspirin poisoning requires immediate fluid resuscitation, titrated bicarbonate infusion, and emergency hemodialysis.