RT Book, Section
A1 J. O, Mary
A2 Reichman, Eric F.
SR Print(0)
ID 1159804242
T1 Subcutaneous Hydration (Hypodermoclysis)
T2 Reichman's Emergency Medicine Procedures, 3e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259861925
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1159804242
RD 2025/04/30
AB Subcutaneous  rehydration  therapy  (SCRT),  also  known  as  hypodermoclysis,  is  a  method  of  fluid  replacement  first  described  in  the  1880s  as  a  proposed  treatment  for  cholera  in  India.1  It  involves  the  infusion  of  fluids  into  the  subcutaneous  space  where  it  slowly  diffuses  into  the  circulation.2  This  method  was  widely  used  for  rehydration  until  the  1950s  until  it  was  superseded  by  the  intravenous  (IV)  route.3  This  was  due  to  reports  of  serious  adverse  events  that  were  most  likely  caused  by  improper  choice  of  fluids  for  SCRT  (e.g.,  shock  secondary  to  osmotic  shift  caused  by  infusion  of  hypertonic  or  electrolyte-free  fluids).4  Subsequent  studies  have  confirmed  the  safety  and  efficacy  of  hypodermoclysis.