RT Book, Section
A1 Smith, Silas W.
A2 Nelson, Lewis S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Smith, Silas W.
A2 Goldfrank, Lewis R.
A2 Hoffman, Robert S.
SR Print(0)
ID 1163002320
T1 Glucarpidase (Carboxypeptidase G2)
T2 Goldfrank's Toxicologic Emergencies, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259859618
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1163002320
RD 2020/08/11
AB Glucarpidase  (carboxypeptidase  G2,  CPDG2)  is  indicated  for  the  management  of  methotrexate  (MTX)  toxicity.  When  given  intravenously  or  intrathecally,  it  rapidly  enzymatically  inactivates  MTX,  folates,  and  folate  analogues.  It  does  not  substitute  for,  and  must  be  used  in  conjunction  with,  leucovorin  (Antidotes  in  Depth:  A12).  Leucovorin  should  not  be  administered  within  2  hours  before  or  after  a  dose  of  glucarpidase.