RT Book, Section
A1 Horner, Fiona Garlich
A1 Hoffman, Robert S.
A1 Nelson, Lewis S.
A1 Howland, Mary Ann
A2 Nelson, Lewis S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Smith, Silas W.
A2 Goldfrank, Lewis R.
A2 Hoffman, Robert S.
SR Print(0)
ID 1163003019
T1 Benzodiazepines
T2 Goldfrank's Toxicologic Emergencies, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259859618
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1163003019
RD 2024/04/20
AB Benzodiazepines  are  a  class  of  sedative–hypnotics  that  share  similar  chemical  structures,  receptor  physiology,  and  clinical  effects.  Benzodiazepines  are  used  broadly  for  a  range  of  clinical  indications,  including  xenobiotic-induced  seizures,  xenobiotic-induced  psychomotor  agitation,  withdrawal  from  ethanol  and  other  sedative–hypnotics,  cocaine-associated  myocardial  ischemia,  chloroquine  overdose,  and  to  induce  muscle  relaxation  in  serotonin  toxicity,  neuroleptic  malignant  syndrome,  strychnine  poisoning,  and  black  widow  spider  envenomation.  This  Antidotes  in  Depth  provides  a  summary  of  the  clinical  pharmacology  of  benzodiazepines  and  a  review  of  their  use  in  ­specific  clinical  scenarios,  with  an  emphasis  on  specific  drug  selection  and  safe  administration.  A  discussion  of  the  manifestations  and  treatment  of  overdose  of  benzodiazepines  and  similar  xenobiotics  is  found  in  Chap.  72.