RT Book, Section
A1 Howland, Mary Ann
A2 Nelson, Lewis S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Smith, Silas W.
A2 Goldfrank, Lewis R.
A2 Hoffman, Robert S.
SR Print(0)
ID 1163003951
T1 Methylene Blue
T2 Goldfrank's Toxicologic Emergencies, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259859618
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1163003951
RD 2024/04/19
AB Methylene  blue  is  an  extremely  effective  antidote  for  acquired  methemoglobinemia.  Methylene  blue  has  other  actions,  including  the  inhibition  of  nitric  oxide  synthase  and  guanylyl  cyclase  and  the  inhibition  of  the  generation  of  oxygen  free  radicals.  These  actions  likely  explain  the  beneficial  effects  of  methylene  blue  in  the  treatment  of  refractory  hypotension,  hepatopulmonary  syndrome,  priapism,  sepsis,  and  malaria;  the  modulation  of  streptozocin-induced  insulin  deficiency;  the  prevention  and  treatment  of  ifosfamide-induced  encephalopathy;  and  the  reduction  of  the  development  of  postsurgical  peritoneal  adhesions.15,16,21,24,34,44,53,64