RT Book, Section
A1 Howland, Mary Ann
A2 Nelson, Lewis S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Smith, Silas W.
A2 Goldfrank, Lewis R.
A2 Hoffman, Robert S.
SR Print(0)
ID 1163007686
T1 Pharmacokinetic and Toxicokinetic Principles
T2 Goldfrank's Toxicologic Emergencies, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259859618
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1163007686
RD 2024/04/19
AB Pharmacokinetics  is  the  study  of  the  absorption,  distribution,  metabolism,  and  excretion  of  xenobiotics.  Xenobiotics  are  substances  that  are  foreign  to  the  body  and  include  natural  or  synthetic  chemicals,  drugs,  pesticides,  environmental  agents,  and  industrial  agents.56  Mathematical  models  and  equations  are  used  to  describe  and  to  predict  these  phenomena.  Pharmacodynamics  is  the  term  used  to  describe  an  investigation  of  the  relationship  of  therapeutic  xenobiotic  concentration  to  its  clinical  effects.  Toxicokinetics,  which  is  analogous  to  pharmacokinetics,  is  the  study  of  the  absorption,  distribution,  metabolism,  and  excretion  of  a  xenobiotic  under  circumstances  that  produce  toxicity.  Toxicodynamics,  which  is  analogous  to  pharmacodynamics,  is  the  study  of  the  relationship  of  toxic  xenobiotic  concentrations  to  their  clinical  effects.