RT Book, Section
A1 Delaney, Kathleen A.
A1 Furmaga, Jakub
A2 Nelson, Lewis S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Smith, Silas W.
A2 Goldfrank, Lewis R.
A2 Hoffman, Robert S.
SR Print(0)
ID 1163008638
T1 Hepatic Principles
T2 Goldfrank's Toxicologic Emergencies, 11e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259859618
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1163008638
RD 2024/04/16
AB The  liver  plays  an  essential  role  in  metabolic  homeostasis.  Hepatic  functions  include  the  synthesis,  storage,  and  breakdown  of  glycogen.  In  addition,  the  liver  is  important  in  the  metabolism  of  lipids;  the  synthesis  of  albumin,  clotting  factors,  and  other  important  proteins;  the  synthesis  of  the  bile  acids  necessary  for  absorption  of  lipids  and  lipid-soluble  vitamins;  and  the  metabolism  of  cholesterol.  Hepatocytes  facilitate  the  excretion  of  metals,  most  importantly  iron,  copper,  zinc,  manganese,  mercury,  and  aluminum,  as  well  as  the  detoxification  of  products  of  metabolism,  such  as  bilirubin  and  ammonia.27,59  Generalized  disruption  of  these  important  functions  results  in  manifestations  of  liver  failure:  hyperbilirubinemia,  coagulopathy,  hypoalbuminemia,  hyperammonemia,  and  hypoglycemia.  Disturbances  of  more  specific  functions  result  in  accumulation  of  lipids,  metals,  and  bilirubin,  and  the  development  of  lipid-soluble  vitamin  deficiencies.125