RT Book, Section A1 Carr, David A1 Nowacki, Anna K. A2 Tintinalli, Judith E. A2 Ma, O. John A2 Yealy, Donald M. A2 Meckler, Garth D. A2 Stapczynski, J. Stephan A2 Cline, David M. A2 Thomas, Stephen H. SR Print(0) ID 1166532418 T1 Arterial Occlusion T2 Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260019933 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1166532418 RD 2023/03/30 AB Limb ischemia occurs when blood flow—and by extension, tissue perfusion—is limited enough to create symptoms; acute limb ischemia denotes rapid new event or a progression of a flow deficit, requiring recognition and rapid therapy for limb salvage. Critical limb ischemia is one end of the spectrum of peripheral arterial disease, when pain at rest, ulceration, or gangrene exists. Smoking and diabetes are the most important risk factors for peripheral arterial disease.1 Additional risk factors include hyperlipidemia, hypertension, elevated blood homocysteine, and an elevated C-reactive protein level.2