RT Book, Section A1 Freire, Gabrielle A1 Shefrin, Allan Evan A1 Zemek, Roger A2 Tintinalli, Judith E. A2 Ma, O. John A2 Yealy, Donald M. A2 Meckler, Garth D. A2 Stapczynski, J. Stephan A2 Cline, David M. A2 Thomas, Stephen H. SR Print(0) ID 1166594104 T1 Wheezing in Infants and Children T2 Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e YR 2020 FD 2020 PB McGraw-Hill Education PP New York, NY SN 9781260019933 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1166594104 RD 2024/04/19 AB Wheezing is a high-pitched sound that occurs when there is an elevation of airway resistance due to an obstructive process. The clinician must differentiate between stridor and wheeze because this determines location of the airway obstruction. Stridor is a sign of upper airway obstruction (above the thoracic inlet) that is more marked during inspiration, whereas wheeze signifies lower airway obstruction distal to the thoracic inlet that is more marked during expiration (see Chapter 126, “Stridor and Drooling in Infants and Children”).1-4 Wheezing implies a generalized obstructive airway disease when diffuse and focal obstruction when localized. However, severe flow limitation may exist without wheezing, for example, the silent chest in a severe asthma exacerbation. Bronchiolitis is the most frequent cause of wheezing in infants, and asthma is the most frequent cause in children and adolescents.