RT Book, Section
A1 Wightman, Rachel S.
A1 Nelson, Lewis S.
A2 Tintinalli, Judith E.
A2 Ma, O. John
A2 Yealy, Donald M.
A2 Meckler, Garth D.
A2 Stapczynski, J. Stephan
A2 Cline, David M.
A2 Thomas, Stephen H.
SR Print(0)
ID 1166600547
T1 Acetaminophen
T2 Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e
YR 2020
FD 2020
PB McGraw-Hill Education
PP New York, NY
SN 9781260019933
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1166600547
RD 2024/04/19
AB Acetaminophen  (N-acetyl-p-aminophenol  or  paracetamol)  is  the  most  popular  over-the-counter  analgesic  and  is  one  of  the  most  common  toxic  exposures  reported  to  poison  centers.  Acetaminophen  (sometimes  abbreviated  APAP)  is  available  as  a  sole  agent  or  combined  with  a  variety  of  other  medications  prepared  in  different  forms,  such  as  tablets,  ­capsules,  gels,  and  liquids.  Although  most  serious  poisonings  involve  intentional  self-harm,  poisonings  often  occur  because  of  the  erroneous  belief  that  this  medication  is  benign  or  because  the  victim  was  unaware  that  acetaminophen  was  an  ingredient  in  the  ingested  preparation.1,2  In  the  United  States,  acetaminophen  is  the  most  common  cause  of  drug-induced  liver  failure  and  accounts  for  almost  half  of  all  cases  of  acute  liver  failure.3,4  Acetaminophen–opioid  combination  products  have  been  implicated  in  chronic  overuse,  likely  due  to  an  increasing  opioid  requirement  leading  to  concomitantly  increasing  acetaminophen  exposure.5  In  response  to  these  safety  concerns,  in  2011,  the  U.S.  Food  and  Drug  Administration  limited  the  prescription  acetaminophen–opioid  combination  preparation  strength  to  325  milligrams  per  dosage  unit  and  now  requires  a  boxed  warning  to  notify  consumers  of  the  potential  risk  for  serious  liver  toxicity.6