RT Book, Section A1 Barlotta, Kevin S. A1 Stack, Lawrence B. A1 Knoop, Kevin J. A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181041057 T1 Sister Mary Joseph Node (Nodular Umbilicus) T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181041057 RD 2023/03/28 AB A Sister Mary Joseph node is a metastasis manifesting as a periumbilical nodule secondary to abdominal or pelvic cancers (one-half are gastrointestinal, one-quarter are gynecologic). Cancers of the colon may cause pain, change in bowel habits, anemia, and obstruction. In general, left-sided cancers cause obstruction, whereas right-sided tumors may have significant metastases before they create signs and symptoms. These metastases typically involve peritoneal and omental spread with distant metastases to the liver. Spread to the umbilicus is colloquially known as the Sister Mary Joseph node.