RT Book, Section A1 Dooley-Hash, Suzanne A1 Knoop, Kevin J. A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181041713 T1 Molar Pregnancy (Hydatidiform Mole) T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181041713 RD 2023/09/24 AB Molar pregnancy is part of a spectrum of gestational trophoblastic tumors that include benign hydatidiform moles, locally invasive moles, and choriocarcinoma. The classic clinical presentation is painless first-trimester or early second-trimester vaginal bleeding with a uterine size larger than the estimated gestational age based on the last menstrual period. Signs of preeclampsia (hypertension, headache, proteinuria, and edema) in the 1st trimester or early 2nd trimester are highly suggestive of this diagnosis as well. Hyperthyroidism is found in roughly 5% of cases. Acute respiratory distress may occur due to embolization of trophoblastic tissue into the pulmonary vasculature, thyrotoxicosis, or simple fluid overload.