RT Book, Section A1 Shah, Ashish A1 Sobolewski, Brad A1 Mittiga, Matthew R. A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181044544 T1 Cat-Scratch Disease T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181044544 RD 2024/10/05 AB Cat-scratch disease is a generally benign, self-limited condition caused primarily by Bartonella henselae that usually manifests with regional lymphadenopathy, although visceral organ, neurologic, or ocular involvement can occur. A history of contact with saliva or scratch from a cat (especially kittens with fleas) is usually present. Cat-scratch disease typically starts with an inoculation lesion, which sequentially will appear vesicular, erythematous, and then papular. Lymphadenopathy near the site of inoculation usually appears within 2 weeks of skin inoculation and may persist for months. In rare cases, patients may develop complications such as ocular disease (neuroretinitis and Parinaud oculoglandular syndrome), encephalitis, osteolytic lesions, hepatosplenic lesions, weight loss, prolonged fever, and fatigue. The differential diagnosis includes lymphogranuloma venereum, bacterial adenitis, sarcoidosis, infectious mononucleosis, tumors (benign or malignant), tuberculosis, tularemia, brucellosis, and histoplasmosis.