RT Book, Section
A1 Hardin, J. Matthew
A2 Knoop, Kevin J.
A2 Stack, Lawrence B.
A2 Storrow, Alan B.
A2 Thurman, R. Jason
SR Print(0)
ID 1181043807
T1 Thrombotic Thrombocytopenic Purpura
T2 The Atlas of Emergency Medicine, 5e
YR 2021
FD 2021
PB McGraw-Hill
PP New York, NY
SN 9781260134940
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181043807
RD 2024/04/20
AB Thrombotic  thrombocytopenic  purpura  (TTP)  was  previously  defined  by  the  following  pentad  of  symptoms:  (1)  microangiopathic  hemolytic  anemia,  (2)  thrombocytopenia,  (3)  renal  abnormalities,  (4)  fever,  and  (5)  neurologic  abnormalities.  However,  at  initial  presentation,  only  10%  of  acute  TTP  patients  have  all  of  these  symptoms.  Most  TTP  patients  will  have  severe  thrombocytopenia  (usually  <  30,000/mm3),  microangiopathic  hemolytic  anemia  (schistocytes  in  the  blood  smear),  and  a  constellation  of  clinical  findings  (petechia,  purpura,  neurologic  symptoms,  myocardial  ischemia,  mesenteric  ischemia,  and  renal  abnormalities).  Approximately  50%  of  TTP  presentations  have  an  associated  comorbidity  that  may  trigger  the  disease  (autoimmune  diseases,  antiphospholipid  syndrome,  pregnancy,  medications,  HIV  infection,  pancreatitis,  malignancy,  and  organ  transplantation),  whereas  the  other  50%  are  idiopathic.