RT Book, Section A1 Hardin, J. Matthew A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181043904 T1 Hidradenitis Suppurativa T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181043904 RD 2023/04/02 AB Hidradenitis suppurativa (HS) most commonly affects obese, postpubertal individuals with a genetic predisposition. This unremitting disease involves intertriginous sites: axillae, inguinal folds, gluteal fold, perianal area, and inframammary folds. Lesions begin with erythematous nodules that become tender and fluctuant. The sterile abscess ruptures with a suppurative discharge, and multiple abscesses can eventuate into sinus tracts and/or fistulae. HS is primarily a noninfectious, inflammatory response to the hair follicle; however, secondary infections are common. Severe hypertrophic scar formation may be dramatic and disfiguring. In addition, chronic discharge is difficult to control and commonly malodorous. The differential diagnosis includes bacterial furunculosis, granuloma inguinale, mycetoma, cutaneous tuberculosis, and fistulas associated with inflammatory bowel disease.