RT Book, Section A1 Williams, Saralyn R. A1 Thurman, R. Jason A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181057174 T1 Peyote Ingestion T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181057174 RD 2024/03/29 AB Peyote (Lophophora williamsii) is a cactus plant found primarily in the southwestern United States. The cactus contains a significant amount of mescaline, a potent hallucinogen with structural similarities to norepinephrine. Peyote buttons and seeds are frequently ingested for recreational use but are also used in the religious ceremonies of some Native American groups. Toxicity of peyote is generally mild and self-limited, but hypotension and respiratory depression can occur. Mescaline induces some sympathomimetic effects due to its similarity to norepinephrine; marked visual hallucinations and a sense of depersonalization follow. These effects are often accompanied by unpleasant GI symptoms such as severe nausea and vomiting. Full recovery from these symptoms usually occurs within a few hours.