RT Book, Section A1 Raffanti, Stephen P. A1 Person, Anna K. A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181057332 T1 Oral Hairy Leukoplakia T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181057332 RD 2024/10/06 AB Oral hairy leukoplakia (OHL) is a disease of the lingual squamous epithelium caused by the Epstein-Barr virus (EBV). OHL generally affects the lateral portion of the tongue, although the floor of the mouth, palate, or buccal mucosa may also be involved. The lesions are white corrugated plaques that, unlike Candida, cannot be scraped from the surface to which they adhere. Most often OHL is asymptomatic, although occasionally this condition can be painful. Diagnosis is usually clinical, although definitive diagnosis can be made by biopsy characteristically revealing acanthosis and parakeratosis.