RT Book, Section A1 Raffanti, Stephen P. A1 Person, Anna K. A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181057439 T1 Herpes Simplex Virus T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181057439 RD 2023/11/30 AB Infection with herpes simplex virus (HSV) is extremely common in HIV-infected patients and may present with oral, genital, anal, esophageal, or ophthalmologic involvement. The hallmark for most clinical presentations of HSV outbreaks is an inflammatory cutaneous eruption, with or without vesicles, and pain. HSV esophagitis is seen in immunocompromised HIV-infected patients and presents as dysphagia and odynophagia with or without oral lesions. Idiopathic aphthous ulcerations in HIV-infected patients are indistinguishable from HSV lesions. Perirectal lesions are often erythematous, ulcerative, and extremely tender, with a predilection for the gluteal cleft. Perirectal HSV may also be associated with proctitis and anal fissures.