RT Book, Section A1 Bales, Brian D. A1 Hensel, Max A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1181053315 T1 Nicotine Use Disorder T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1181053315 RD 2024/04/24 AB Nicotine is a naturally occurring alkaloid found primarily in tobacco. Nicotine delivery methods include cigarettes, pipe and cigar tobacco, smokeless tobacco, electronic cigarettes, nicotine gum, and lozenges. Long-term complications of nicotine use include coronary artery disease, stroke, peripheral vascular disease, thromboangiitis obliterans (Fig. 27.22A), chronic obstructive lung disease, and oropharyngeal and pulmonary malignancies. Lighting a cigarette while using supplemental oxygen may cause flash burns (Fig. 27.23). Cigarette smoking also causes staining of nails and teeth due to both direct staining from tar and nicotine as well as vascular vasoconstriction mediated by the nicotine and carbon monoxide present in tobacco smoke (Fig. 27.22B). More recently, the increased use of electronic cigarettes (vaping) has resulted in a rise in e-cigarette– and vaping-associated lung injury (EVALI) with typical manifestations of bilateral ground-glass opacities on chest CT (Figs. 27.25 and 27.26).