RT Book, Section
A1 Shah, Ashish
A1 Sobolewski, Brad
A1 Mittiga, Matthew R.
A2 Knoop, Kevin J.
A2 Stack, Lawrence B.
A2 Storrow, Alan B.
A2 Thurman, R. Jason
SR Print(0)
ID 1177127227
T1 Hand, Foot, And Mouth Syndrome
T2 The Atlas of Emergency Medicine, 5e
YR 2021
FD 2021
PB McGraw-Hill
PP New York, NY
SN 9781260134940
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1177127227
RD 2021/01/17
AB Hand,  foot,  and  mouth  syndrome  (HFMS)  is  a  seasonal  (summer-fall)  viral  infection  caused  most  frequently  by  coxsackievirus  A16,  with  other  enterovirus  serotypes  implicated  less  frequently.  Toddlers  and  school-aged  children  are  affected  most  commonly,  although  adults  may  also  be  affected.  It  is  characterized  by  a  prodrome  of  fever,  malaise,  sore  throat,  and  anorexia  over  1  to  2  days,  followed  by  the  appearance  of  the  characteristic  enanthem  in  the  posterior  oropharynx  and  tonsillar  pillars  consisting  of  small,  red  macules  evolving  into  small  vesicles  1  to  3  mm  in  diameter  that  rapidly  ulcerate.  Oral  manifestations  are  followed  by  a  vesicular  eruption  characterized  by  3-  to  7-mm  erythematous  macules  with  a  central  gray  vesicle  on  the  hands  and  feet  involving  the  palmar  and  plantar  surfaces  and  interdigital  surfaces.  A  nonvesicular  rash  may  also  be  present  on  the  buttocks,  face,  and  legs.