RT Book, Section A1 Shah, Ashish A1 Sobolewski, Brad A1 Mittiga, Matthew R. A2 Knoop, Kevin J. A2 Stack, Lawrence B. A2 Storrow, Alan B. A2 Thurman, R. Jason SR Print(0) ID 1177127409 T1 Branchial Cleft Cyst T2 The Atlas of Emergency Medicine, 5e YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781260134940 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1177127409 RD 2021/01/17 AB A branchial cleft cyst arises from the incomplete obliteration of one of the four branchial clefts during embryogenesis. As obliteration of the clefts occurs, a portion may remain, forming a cystic space with an epithelial lining and no connection to the skin or pharynx. The anatomic location of a branchial cleft cyst depends on the specific arch/cleft involved. Involvement of the 1st cleft may result in a cyst in the region of the parotid gland, the preauricular or postauricular area, or inferior to the angle of the mandible. Second cleft anomalies represent 70% to 90% of cysts and may be found along the anterior border of or deep to the sternocleidomastoid muscle, in the vicinity of the carotid arteries. Third and 4th arch/cleft anomalies are rare. A cyst usually presents clinically as a lateral, tender neck mass due to acute infection and enlargement usually in association with an upper respiratory infection.