RT Book, Section
A1 Williams, Saralyn R.
A1 Thurman, R. Jason
A2 Knoop, Kevin J.
A2 Stack, Lawrence B.
A2 Storrow, Alan B.
A2 Thurman, R. Jason
SR Print(0)
ID 1177128778
T1 Vancomycin-Induced Red Man Syndrome
T2 The Atlas of Emergency Medicine, 5e
YR 2021
FD 2021
PB McGraw-Hill
PP New York, NY
SN 9781260134940
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1177128778
RD 2021/01/24
AB Vancomycin  has  activity  against  gram-positive  bacteria  with  little  to  no  activity  against  gram-negative  bacteria  or  mycobacteria.  It  is  poorly  absorbed  after  oral  administration,  although  it  may  be  used  orally  for  treatment  of  pseudomembranous  colitis.  Intravenous  administration  is  the  most  common  route.  This  is  well  tolerated  with  minimal  burning  at  the  site  of  the  intravenous  line;  however,  rapid  infusion  may  occasionally  cause  degranulation  of  mast  cells  and  basophils.  As  a  result,  the  patient  experiences  erythematous  flushing,  particularly  of  the  face  and  neck,  hence  the  name  “red  man  syndrome.”  Tachycardia  and  hypotension  may  occasionally  be  seen.