RT Book, Section A1 Synovitz, Carolyn K. A2 Cline, David M. A2 Ma, O. John A2 Cydulka, Rita K. A2 Meckler, Garth D. A2 Handel, Daniel A. A2 Thomas, Stephen H. SR Print(0) ID 56272446 T1 Chapter 28. Occlusive Arterial Disease T2 Tintinalli's Emergency Medicine Manual, 7e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-178184-8 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=56272446 RD 2024/04/24 AB Peripheral arterial disease is defined as an ankle-brachial index (ABI) of <0.9 (see ABI definition below). The disease prevalence is 4.3% in Americans under age 40 years; prevalence climbs to 15.5% in those over 70 years of age. High-risk individuals (such as those over 70 years, or those over 50 years with risk factors such as diabetes or tobacco use), should be evaluated carefully when complaints are indicative of possible occlusive arterial disease. This time-sensitive condition can lead to irreversible changes in peripheral nerves and skeletal muscle tissue in 4 to 6 hours. The most frequently involved arteries, in descending order, are the femoropopliteal, tibial, aortoiliac, and brachiocephalic.