RT Book, Section A1 Cline, David M. A2 Cline, David M. A2 Ma, O. John A2 Cydulka, Rita K. A2 Meckler, Garth D. A2 Handel, Daniel A. A2 Thomas, Stephen H. SR Print(0) ID 56275380 T1 Chapter 95. Malaria T2 Tintinalli's Emergency Medicine Manual, 7e YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-178184-8 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=56275380 RD 2022/08/18 AB Malaria must be considered in any person who has traveled to the tropics and presents with an unexplained febrile illness. Five species of the protozoan Plasmodium infect humans: P falciparum, P vivax, P ovale, P malariae, and P knowlesi. The organism is transmitted by the anopheline mosquito bite and travels hematogenously first to the liver, where asexual reproduction occurs (exoerythrocytic stage). The liver cell ruptures, releasing merozoites that invade erythrocytes, multiply, and cause hemolysis (erythrocytic stage). Malaria also may be transmitted by blood transfusion or passed transplacentally from mother to fetus.