RT Book, Section A1 Chiu, William A1 Marcolini, Evie A1 Chiu, William C. A2 Farcy, David A. A2 Chiu, William C. A2 Flaxman, Alex A2 Marshall, John P. SR Print(0) ID 55813981 T1 Chapter 33. Adrenal Insufficiency T2 Critical Care Emergency Medicine YR 2012 FD 2012 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-162824-2 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=55813981 RD 2024/04/25 AB Adrenal gland function has provided great academic material for investigation and controversy. It was not until 1937 that 17-hydroxy-11-dehydrocorticosterone, or cortisone, was isolated by Reichstein from the adrenal cortex. By 1947, synthetic cortisone was developed. At the same time, in addition to the use of cortisone for Addison's disease, this compound was found to have a therapeutic effect in patients with rheumatoid pain through its ability to inhibit stress and inflammation.