RT Book, Section A1 Reichman, Eric F. SR Print(0) ID 57713921 T1 Chapter 127. Intravenous Regional Anesthesia T2 Emergency Medicine Procedures, 2e YR 2013 FD 2013 PB The McGraw-Hill Companies PP New York, NY SN 978-0-07-161352-1 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=57713921 RD 2024/04/23 AB The technique of intravenous regional anesthesia (IVRA) was first introduced by August Bier in 1908.1 IVRA essentially consists of injecting local anesthetic solution into the venous system of an extremity (upper or lower) that has been exsanguinated by compression and/or gravity and isolated from the central circulation by means of a tourniquet. Procaine in concentrations of 0.25% to 0.5% was injected through an intravenous cannula placed between two Esmarch bandages utilized as tourniquets to divide the arm into proximal and distal compartments in Bier's original technique.2–4 He noted two distinct types of anesthesia. The first was an almost immediate onset of “direct” anesthesia between the two tourniquets. An “indirect” anesthesia distal to the distally placed tourniquet was noted after a delay of 5 to 7 minutes. This technique was eventually renamed the Bier block.