RT Book, Section
A1 Karydes, Harry C.
A2 Sherman, Scott C.
A2 Weber, Joseph M.
A2 Schindlbeck, Michael A.
A2 Rahul G., Patwari
SR Print(0)
ID 1101225994
T1 Cyclic Antidepressants
T2 Clinical Emergency Medicine
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-179460-2
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1101225994
RD 2024/04/19
AB Cyclic  antidepressants  remain  a  leading  cause  of  poisoning-related  fatalities  among  psychoactive  medications.Patients  will  frequently  present  with  minimal  signs  and  symptoms  only  to  abruptly  decompensate  from  life-threatening  cardiovascular  and  central  nervous  system  toxicity.Cardiovascular  toxicity  (specifically  refractory  hypotension)  is  the  leading  cause  of  morbidity  and  mortality  in  cyclic  antidepressant  overdose.Hypertonic  sodium  bicarbonate  should  be  given  in  1–2  mEq/kg  boluses  to  reverse  the  wide-complex  dysrhythmias  commonly  encountered  with  cyclic  antidepressant  poisoning.