RT Book, Section
A1 Howland, Mary Ann
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108422090
T1 Antidotes in Depth
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1108422090
RD 2024/04/18
AB Protamine  is  a  rapidly  acting  antidote  that  is  used  primarily  to  reverse  the  anticoagulant  effects  of  unfractionated  heparin  (UFH).  It  neutralizes  the  anti-IIa  activity  of  low-molecular-weight  heparin  (LMWH)  and  incompletely  neutralizes  the  anti-Xa  activity  of  LMWH,  which  may  normalize  activated  partial  thromboplastin  time  (aPTT)  and  the  thrombin  time,  but  variably  resolves  clinical  bleeding.  Protamine  has  no  effect  on  heparin  pentasaccharide  fragments  or  analogs  such  as  fondaparinux.