RT Book, Section A1 Hoffman, Robert S. A1 Nelson, Lewis S. A1 Howland, Mary Ann A2 Hoffman, Robert S. A2 Howland, Mary Ann A2 Lewin, Neal A. A2 Nelson, Lewis S. A2 Goldfrank, Lewis R. SR Print(0) ID 1108422446 T1 Antidotes in Depth T2 Goldfrank's Toxicologic Emergencies, 10e YR 2015 FD 2015 PB McGraw-Hill Education PP New York, NY SN 9780071801843 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1108422446 RD 2024/10/04 AB Benzodiazepines are used as first-line anticonvulsants for virtually all xenobiotic induced seizures; as sedatives of choice for most forms of xenobiotic induced agitation; as muscle relaxants for diverse disorders such as serotonin toxicity, neuroleptic malignant syndrome, and poisoning from strychnine or black widow spider envenomation; and as ­sedatives for withdrawal from ethanol, γ-hydroxybutyric acid, and other ­sedatives. Additional distinct indications for benzodiazepines can be found in overdose from chloroquine and possibly other quinine derived antimalarials, and in patients with cocaine associated myocardial ischemia and infarction. This Antidotes in Depth provides a summary of the clinical pharmacology of benzodiazepines in order to provide the reader with the background necessary to administer these drugs as safely and effectively as possible.