RT Book, Section
A1 Rao, Rama B.
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108426477
T1 Neurologic Principles
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1108426477
RD 2024/04/18
AB The  central  nervous  system  (CNS)  coordinates  responses  to  the  fluctuating  metabolic  requirements  of  the  body  and  modulates  behavior,  memory,  and  higher  levels  of  thinking.  These  functions  require  a  diversity  of  cells:  astrocytes,  neurons,  ependymal  cells,  and  vascular  endothelial  cells.  Disruption  or  death  of  any  one  cell  type  can  cause  critical  changes  in  the  function  or  viability  of  another.  This  cellular  interdependence,  along  with  the  high  metabolic  demands  of  the  CNS,  makes  neurons  especially  vulnerable  to  injury  from  both  endogenous  neurotoxins  and  xenobiotics.  Endogenous  neurotoxins,  such  as  the  metals  iron,  copper,  and  manganese,  are  substances  that  may  be  critical  to  CNS  function  but  are  harmful  when  their  penetration  into  the  CNS  is  poorly  controlled.