RT Book, Section
A1 Eddleston, Michael
A2 Hoffman, Robert S.
A2 Howland, Mary Ann
A2 Lewin, Neal A.
A2 Nelson, Lewis S.
A2 Goldfrank, Lewis R.
SR Print(0)
ID 1108435876
T1 Insecticides: Organic Phosphorus Compounds and Carbamates
T2 Goldfrank's Toxicologic Emergencies, 10e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071801843
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1108435876
RD 2024/04/19
AB The  first  potent  synthetic  organic  phosphorus  anticholinesterase,  tetraethylpyrophosphate  (TEPP),  was  synthesized  by  Clermont  in  1854.  Clermont’s  report  described  the  taste  of  the  compound,  a  remarkable  achievement  because  a  few  drops  should  be  rapidly  fatal.111  In  1932,  Lange  and  Krueger  wrote  of  choking  and  blurred  vision  following  inhalation  of  dimethyl  and  diethyl  phosphorofluoridates.  This  account  inspired  Schrader  in  Germany  to  begin  investigating  these  agents,  initially  as  pesticides,  and  later  for  use  in  warfare  (Chap.  132).  During  this  research,  Schrader’s  group  synthesized  hundreds  of  compounds,  including  the  popular  pesticide  parathion  and  the  chemical  weapons  sarin,  soman,  and  tabun.  Allied  scientists  were  also  motivated  during  the  same  period  by  the  work  and  independently  discovered  other  extremely  toxic  compounds  such  as  diisopropylphosphofluoridate  (DFP).214  Since  that  time,  it  is  estimated  that  more  than  50,000  organic  phosphorus  compounds  have  been  synthesized  and  screened  for  pesticidal  activity,  with  dozens  being  produced  commercially.40