RT Book, Section A1 Sivilotti, Marco L. A. A2 Schafermeyer, Robert A2 Tenenbein, Milton A2 Macias, Charles G. A2 Sharieff, Ghazala Q. A2 Yamamoto, Loren G. SR Print(0) ID 1105686424 T1 Aspirin T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 4e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-182926-7 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1105686424 RD 2024/04/20 AB Salicylate poisoning is difficult to treat, and consideration should be given to consultation with a medical toxicologist.Children with aspirin toxicity can rapidly develop metabolic acidosis without an apparent respiratory alkalosis.Initial treatment decisions should be predicated on the presence of symptoms, hearing distortion, mental status, tachypnea, and blood gas measurements rather than waiting for a salicylate concentration.Treatment of mild-to-moderate aspirin poisoning consists of slowing ongoing absorption, correcting volume and electrolyte deficits, alkalinizing the urine and frequent clinical and laboratory reassessments.Severe aspirin poisoning requires immediate fluid resuscitation, titrated bicarbonate infusion, and emergency hemodialysis.