RT Book, Section A1 Meehan, Timothy J. A1 Marcucci, Jared J. A2 Schafermeyer, Robert A2 Tenenbein, Milton A2 Macias, Charles G. A2 Sharieff, Ghazala Q. A2 Yamamoto, Loren G. SR Print(0) ID 1105686735 T1 Psychotherapeutic Drugs T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 4e YR 2014 FD 2014 PB McGraw-Hill Education PP New York, NY SN 978-0-07-182926-7 LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1105686735 RD 2024/03/29 AB The key targets of antidepressant and neuroleptic poisoning are the cardiovascular and central nervous systems.Tricyclic antidepressant poisoning is potentially life threatening due to ventricular dysrhythmias and hypotension. Treatment is supportive with consideration given to sodium bicarbonate for dysrhythmia prevention and treatment, and to pressors for hypotension.Children who are asymptomatic for 6 hours after the ingestion of antidepressants or neuroleptics may be discharged from the ED.The serotonin syndrome (SS) is a life-threatening condition manifested by mental status changes, autonomic instability, hyperthermia, and neuromuscular abnormalities such as hyperreflexia and tremors. Its treatment is supportive with consideration given to cyproheptadine.The neuroleptic malignant syndrome (NMS) is a life-threatening condition manifested by hyperthermia, skeletal muscle rigidity, and altered mental status. Its treatment is supportive with particular attention to cooling and consideration given to bromocriptine.Overdose of typical neuroleptics may produce an acute dystonic reaction, which can be reversed with diphenhydramine or benztropine mesylate.