RT Book, Section
A1 Barker, Kimberly
A1 Seger, Donna
A2 Schafermeyer, Robert
A2 Tenenbein, Milton
A2 Macias, Charles G.
A2 Sharieff, Ghazala Q.
A2 Yamamoto, Loren G.
SR Print(0)
ID 1105686825
T1 Oral Anti-Diabetic Agents
T2 Strange and Schafermeyer's Pediatric Emergency Medicine, 4e
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 978-0-07-182926-7
LK accessemergencymedicine.mhmedical.com/content.aspx?aid=1105686825
RD 2024/04/23
AB Oral  anti-diabetic  drugs  function  by  either  increasing  insulin  secretion  or  by  modulating  blood  glucose  concentrations  through  a  variety  of  mechanisms  other  than  the  increase  of  blood  insulin  concentration.Significant  poisoning  is  associated  with  sulfonylureas  and  metformin  only.Sulfonylurea  overdose  can  produce  life-threatening  hypoglycemia,  and  the  antidote  of  choice  is  octreotide.It  is  inadvisable  to  administer  prophylactic  intravenous  dextrose  to  normoglycemic  children  with  sulfonylurea  ingestion  because  this  may  mask  and  prolong  the  appearance  of  sulfonylurea-induced  hypoglycemia.Asymptomatic,  euglycemic  young  children  presenting  with  a  history  of  sulfonylurea  ingestion  require  8  hours  of  observation  and  no  prophylactic  intravenous  dextrose  therapy.Metformin  overdose  can  result  in  life-threatening  lactic  acidosis  that  may  require  hemodialysis.